Table III.
Top six canonical pathways enriched by IPA.
| Ingenuity canonical pathways | Log (P-value) | Ratio | Molecules |
|---|---|---|---|
| LXR/RXR activation | 5.70 | 0.0331 | APOA1, APOA4, APOA2, VTN |
| FXR/RXR activation | 5.63 | 0.0317 | APOA1, APOA4, APOA2, VTN |
| Atherosclerosis signaling | 3.92 | 0.0236 | APOA1, APOA4, APOA2 |
| Phagosome formation | 3.88 | 0.0229 | FN1, VTN, FCGR3A/FCGR3B |
| IL-12 signaling and production in macrophages | 3.74 | 0.0205 | APOA1, APOA4, APOA2 |
| Glutathione-mediated detoxification | 3.59 | 0.0645 | GGH, ANPEP |
FXR/RXR, farnesoid X receptor/retinoid X receptor; IL, interleukin; LXR/RXR, liver X receptor/retinoid X receptor.