Table 3.
ITD and maintenance doses of antiepileptic drugs in adults
| Drug | ITD (mg/day) | MD (mg/day) | DDD* (mg) |
|---|---|---|---|
| Carbamazepine | 400–600 | 400–1,200 | 1000 |
| Clobazam | 10 | 10–40 | 8 |
| Eslicarbazepine | 800 | 800–1,200 | 800 |
| Ethosuximide | 500 | 500–1,500 | 1,250 |
| Gabapentin | 900 | 900–3,600 | 1,800 |
| Lacosamide | 200 | 200–400 | 300 |
| Lamotrigine | 150 (monotherapy) | 200–400 | 300 |
| Lamotrigine | 75 (with valproic acid) | 75–200 | |
| Lamotrigine | 300 (with enzyme inducer) | 200–500 | |
| Levetiracetam | 1,000 | 1,000–3,000 | 1,500 |
| Oxcarbazepine | 600 | 600–2,400 | 1,000 |
| Perampanel | 4 | 4–12 | 8 |
| Phenobarbital | 60 | 60–120 | 100 |
| Phenytoin | 200 | 200–400 | 300 |
| Pregabalin | 300 | 300–600 | 300 |
| Primidone | 500 | 500–1,500 | 1,250 |
| Rufinamide | 1,200 | 1,200–3,200 | 1,400 |
| Topiramate | 100 | 100–400 | 300 |
| Valproic acid | 500 | 500–2,000 | 1,500 |
| Vigabatrin | 1,000 | 1,000–3,000 | 2,000 |
| Zonisamide | 200 | 200–600 | 200 |
ITD, initial target dose; MD, maintenance dose; DDD, defined daily dose.
*
By World Health Organization.