Table 1.
Linearity parameters of the RP-HPLC stability indicating method
Parameters | CIL/PVP physical mixture | CIL/PVP solid dispersion |
---|---|---|
Linearity range mg mL-1 | 0.08 – 0.4 | 0.08 – 0.4 |
Regression equations | Y = a c +b | |
Slope a ± | 4.955 ± 0.239 | 4.941 ± 0.225 |
Sa | 1.039 | 1.028 |
*Intercept b ± | 0.0237 ± 0.0059 | 0.0221 ± 0.0067 |
Sb | 0.0258 | 0.0239 |
Regression coefficient | 0.998 | 0.998 |
Sy | 0.0377 | 0.0371 |
LOD mg mL-1 | 0.025 | 0.025 |
LOQ mg mL-1 | 0.073 | 0.073 |
Intercept b from equation y = ac + b was statistically insignificant (t-Student test, α = 0.05); S , S , S standard deviation of slope a, intercept b and y, respectively.