Table 3.
Associations (odds ratio (95% CI)) of continuous SMFQ scores at ages 9–13 years with chronic disabling fatigue (CDF) at age 16 years (SMFQP = completed by parent, SMFQC = completed by child).
| Raw data | Imputed data† | Imputed data† (excluding comorbid depressive symptoms) | ||
|---|---|---|---|---|
| SMFQP at age 9 yrs (mean 9.7 yrs) | Partially adjusted# | 1.19 (1.13, 1.26) | 1.15 (1.10, 1.21) | 1.10 (1.02, 1.17) |
| Fully adjusted‡ | – | 1.07 (1.01, 1.13) | 1.04 (0.97, 1.13) | |
| SMFQC at age 10 yrs (mean 10.6 yrs) | Partially adjusted# | 1.13 (1.06, 1.20) | 1.12 (1.07, 1.17) | 1.06 (1.05, 1.06) |
| Fully adjusted‡ | – | 1.06 (1.01, 1.12) | 1.02 (0.95, 1.10) | |
| SMFQP at age 11 yrs (mean 11.7 yrs) | Partially adjusted# | 1.15 (1.09, 1.22) | 1.16 (1.10, 1.21) | 1.09 (1.09, 1.10) |
| Fully adjusted‡ | – | 1.07 (1.01, 1.14) | 1.04 (0.96, 1.12) | |
| SMFQC at age 12 yrs (mean 12.8 yrs) | Partially adjusted# | 1.12 (1.05, 1.19) | 1.14 (1.09, 1.20) | 1.03 (0.96, 1.09) |
| Fully adjusted‡ | – | 1.11 (1.07, 1.16) | 0.99 (0.92, 1.06) | |
| SMFQP at age 13 yrs (mean 13.2 yrs) | Partially adjusted# | 1.15 (1.10, 1.21) | 1.15 (1.11, 1.20) | 1.09 (1.08, 1.09) |
| Fully adjusted‡ | – | 1.09 (1.04, 1.14) | 1.04 (0.98, 1.11) | |
| SMFQC at age 13 yrs (mean 13.8 yrs) | Partially adjusted# | 1.13 (1.07, 1.20) | 1.11 (1.07, 1.16) | 1.03 (1.02, 1.03) |
| Fully adjusted‡ | – | 1.07 (1.02, 1.12) | 0.99 (0.92, 1.07) |
† Variables for the multiple imputation were: CDF @ 13y & 16y; sex; nighttime sleep duration @ 7y & 9y; BMI @ 7y & 9y; child mood @ 9y, 10y, 11y, 12y, 13y (Short Moods and Feelings Questionnaire score); maternal depression @ 11y (Edinburgh Postnatal Depression Scale); maternal anxiety @ 11y (Crown-Crisp Experiential Index); mean test score for English, Mathematics and Science @ 11y (Key Stage 2 tests); maternal life events score (antenatal); self-esteem @ 8y (Global Self Worth subscale from Harter's Self Perception Profile for Children); ALSPAC family adversity index (antenatal); family adversity index @8-10y; life difficulties, hyperactivity and internalising behaviour @ 11y (Strengths and Difficulties Questionnaire); screen time @ 6y; special school arrangements for emotional/behavioural problems @ 7y; conduct problems @ 8y; duration of breastfeeding; family income @ 4y; maternal childhood socioeconomic status; maternal education; maternal age at birth of child; maternal psychopathology @ 8-10y; experienced bullying @ 8y; days spent outdoors @ 8y; poor concentration at school @ 7y; maternal and paternal BMI @ 8y; internalising behaviour @ 4y (Strengths and Difficulties Questionnaire); early puberty; dietary patterns @ 3y & 10y; physical activity @ 11y & 13y (total accelerometer counts per minute over 7-day period).
# Adjusted for sex and family adversity index (antenatal).
‡ Adjusted for: sex; family adversity index (antenatal); BMI @ 7y & 9y; maternal depression @ 11y; maternal anxiety @ 11y; internalising behaviour @ 4y & 11y; self-esteem @ 8y; child mood @ 9y; early puberty; Key Stage 2 test scores; duration of breastfeeding; family income @ 4y; screen time @ 6y; maternal childhood socioeconomic status; maternal life events score (antenatal); nighttime sleep duration @ 8y; conduct problems @ 8y; dietary patterns @ 10y