Table 3.
Maximal response (EMAX) and potency values (pEC50) obtained from concentration-response curves to acetylcholine (ACh) and U44619 in mice thoracic aorta PVAT− and PVAT+ from sedentary (c-SD), trained (c-TR), obese sedentary (o-SD), and obese trained (o-TR) groups.
| c-SD | c-TR | o-SD | o-TR | ||
|---|---|---|---|---|---|
| ACh | EMAX (%) | 78.4 ± 1.0 (6) | 86 ± 3 (5) | 68 ± 3* (8) | 78 ± 3+ (5) |
| PVAT- | pEC50 | 6.71 ± 0.08 | 7.35 ± 0.17* | 6.46 ± 0.08 | 6.61 ± 0.04# |
| ACh | EMAX (%) | 75 ± 1.5 (7) | 84 ± 3.8 (5) | 56 ± 2.9* (8) | 75 ± 3.8+ (5) |
| PVAT+ | pEC50 | 6.60 ± 0.10 | 7.21 ± 0.15 | 6.07 ± 0.14 | 6.83 ± 0.37 |
| U46619 | EMAX (mN/mm) | 9.1 ± 0.9 (5) | 6.7 ± 0.3* (5) | 9.5 ± 1.1 (7) | 5.8 ± 0.3+ (8) |
| PVAT- | pEC50 | 7.7 ± 0.09 | 7.5 ± 0.09 | 7.6 ± 0.05 | 7.6 ± 0.11 |
| U46619 | EMAX (mN/mm) | 9.3 ± 0.9 (5) | 6.9 ± 0.5* (5) | 9.3 ± 0.8 (7) | 6.4 ± 0.6+ (8) |
| PVAT+ | pEC50 | 7.4 ± 0.06 | 7.5 ± 0.15 | 7.4 ± 0.08 | 7.6 ± 0.09 |
Potency is represented as −log of molar concentration to produce 50% of the maximal responses. Data are mean ± SEM. The number of animals per group is indicated in the parentheses. Two-way ANOVA: *p < 0.05 compared with the c-SD; +p < 0.05 compared with the o-SD; #p < 0.05 compared with the c-TR.