Table 1.

Statistics for 10 low-energy Ixolaris models

Number of NMR distance restraints	38
Restraints eliminated because of distance violations*
Between 1 and 2 Å/structure†	0.4 ± 0.4
Above 5.0 Å/structure	0.0 ± 0.0
Number of disulfide restraints‡	5
Ramachandran statistics¶
% of residues in favored regions	91.9
% of residues in allowed regions	99.9
Outliers	0
Average RMSD to mean structure (Å)§
Backbone atoms	1.39 ± 0.58
Heavy atoms	1.53 ± 0.63

^*Violations were calculated using 5 Å universal upper bound distance for structurally degenerate and unambiguous NOE restraints

^†One NOE has violated in 4 structures.

^‡Disulfide restraints were used between the pairs of residues: 18-68, 26-51, 43-64, 76-126, and 101-122.

^¶Ramachandran statistics were calculated using MOLPROBITY over the low-energy models.

^§Computed over 10 low-energy structures for core residues 2-7, 20-25, 29-35, 49-58, 76-83, 87-94, 107-115.