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. 2019 Aug 16;10:1887. doi: 10.3389/fimmu.2019.01887

Figure 1.

Figure 1

IFN-γ-dependent expansion of monocyte-derived dendritic cells during acute infection. (A) Gating strategies of cDCs and moDCs in the spleen of naïve or LCMV-Arm-infected mice. Numbers indicate the percentages within the gates. (B) Cell numbers and frequencies of cDCs and moDCs in the spleen during LCMV-Arm infection. (C) Expression patterns of indicated surface molecules on cDCs and moDCs in LCMV-Arm-infected mice at day 4 p.i., Numbers indicate the MFI values of each molecule. (D) Kinetics of IFN-γ levels in the serum of LCMV-Arm-infected mice. (E,F) LCMV-Arm-infected mice were treated with IFN-γ-neutralizing Ab. (E) Cell numbers (left) and frequencies (right) of cDCs and moDCs were measured in the indicated organs on day 8 p.i., and are shown as graph plots. (F) Frequency of moDCs in the BM. Data are representative of three independent experiments and are shown as the mean ± SEM. n = 5 per group at each time point. **p < 0.01;***p < 0.001.