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. 2019 Aug 16;10:1887. doi: 10.3389/fimmu.2019.01887

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Copyright © 2019 Shin, Jeon, Kim, Kim, Park, Koh, Song, Lee, Lim, Bae, Seo, Ban, Ha and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Defective IL-2 signaling grants moDCs an ability to induce memory CD8⁺ T cells. (A) IL-2 concentrations in the supernatant from the cultures of P14 cells with cDCs or moDCs. (B) Gene expression levels of Il2 in cDCs and moDCs isolated from LCMV-Arm-infected splenocytes. (C–F) Recombinant IL-2 or anti-IL-2 mAbs were added to the cultures of P14 cells with moDCs or cDCs. (C,D) Coexpressions of CD25 and CD62L under each condition are shown as flow cytometry plots (C) and graphs (D). (E,F) Expression levels of TCF1 are shown as flow cytometry plots (E) and graph (F). Numbers in the plots indicate the percentage within each gate. Data are representative of two independent experiments and are shown as the mean ± SEM. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001.