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. Author manuscript; available in PMC: 2019 Aug 23.
Published in final edited form as: Reprod Toxicol. 2017 May 17;70:82–96. doi: 10.1016/j.reprotox.2017.05.005

Fig. 2.

Fig. 2.

Microvessel Outgrowth Inhibition Dose-response. Rat aortic explants were incubated in the absence or presence of increasing concentrations of (A) 5HPP-33 or (B) TNP-470 for four days followed by image acquisition and outgrowth quantification. Integrated density values of the microvessel outgrowth were normalized to the values at the beginning of treatment. Data are expressed as the mean relative (normalized) integrated density ± SD. Samples sizes are shown in the respective figures. Nonlinear regression analysis was used to estimate the concentration that inhibited 50% of the microvessel outgrowth relative to the untreated explants (EC50) using nonlinear curve fitting software. * Statistically different from the untreated group via 1-way ANOVA with Dunnett’s Multiple Comparison Test at P < 0.05.