Table 2.
ToxCast in vitro HTS Assay Findings.
| Source | Total Assay Endpoints | Number of Active Assay Endpoints (% of Source) | Number Active in the 25th Percentile AC50 values (% of Source) | |||
|---|---|---|---|---|---|---|
| 5HPP-33 | TNP-470 | 5HPP-33 | TNP-470 | 5HPP-33 | TNP-470 | |
| ACEA | 2 | 0 | 2 (100) | 0 | 1 (50.0) | 0 |
| APR | 39 | 39 | 17 (43.6) | 0 | 7 (41.2) | 0 |
| Attagene | 163 | 163 | 40 (24.5) | 14 (8.6) | 5 (12.5) | 3 (21.4) |
| BioSeek | 174 | 174 | 65 (37.4) | 43 (24.7) | 9 (13.8) | 6 (37.5) |
| CeeTox | 20 | 20 | 9 (45.0) | 0 | 1 (11.1) | 0 |
| NCCT | 1 | 4 | 0 | 1 (25.0) | 0 | 0 |
| NHEERL ZF | 1 | 1 | 1 (100) | 0 | 1 (100) | 0 |
| Novascreen | 338 | 326 | 14 (4.4) | 4 (1.2) | 9 (64.3) | 4 (100) |
| OT | 17 | 17 | 6 (35.3) | 1 (5.9) | 5 (83.3) | 0 |
| Tanguay ZF | 19 | 19 | 2 (10.5) | 8 (42.1) | 0 | 8 (100) |
| Tox21 | 113 | 113 | 47 (41.6) | 11 (9.7) | 9 (19.1) | 1 (9.1) |
| Assay Summary | Number of assays | Number of Active Assay Endpoints (% of Total) | Number Active in the 25th Percentile AC50 values (% of Total) | |||
| 5HPP-33 | TNP-470 | 5HPP-33 | TNP-470 | 5HPP-33 | TNP-470 | |
| Totals | 887 | 876 | 202 (22.8) | 82 (9.4) | 47(25) | 21 (25) |
| Median AC50 ± SD (μM) | NA | NA | 18.7 ± 30 | 6.6 ± 9.6 | 3.63 ± 2.2 | 0.45 ± 1.3 |