Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 22;20:437. doi: 10.1186/s12859-019-3028-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 1 — Overall workflow of the study. a, workflow of real data analysis. CMAP and LINCS datasets are analyzed by principal component analysis, followed by differential expression analysis with several batch effect correction methods, which were then evaluated by connectivity mapping (the procedure of connectivity mapping is illustrated by Additional file 2: Figure S2); b, workflow of simulation analysis. Expression data were simulated from CMAP dataset, and the optimal number of largest principal components being corrected for was assessed