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. 2019 Aug 22;38:373. doi: 10.1186/s13046-019-1383-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — (a) Cytotoxic activity of Bionanofenretinide (Bio-nFeR) in comparison with standard formulation fenretinide (NCI-FeR) in lung CSC. Lung CSC were exposed to the indicated drug doses and cell viability was evaluated by CellTiter-Glo after 72 h and indicated as percentage versus control cells. b Bio-nFeR and NCI-FeR antitumour activity in lung CSC-derived xenografts. (left) Growth curves of lung CSC-derived xenografts in control mice or mice treated with Bio-nFeR or NCI-FeR at 50 mg/kg dose for the indicated times. Lung CSC sample #136 was used for xenograft generation. Mean ± S.D. of three independent experiments is shown. **P < 0.01. (right) Table of drug-induced systemic toxicity in the three groups of mice indicated as percentage of body weight loss (BWL) or number of deaths/total number of mice