Table 1.
Bio-nFeR pharmacokinetic parameters
| Bio-nFeR pharmacokinetic parameters | ||||
|---|---|---|---|---|
| Bio-nFer Dose (mg/kg) | 10 | 50 | 100 | 200 |
| Cmax (ng/ml) | 600.9 | 3654.7 | 5340.9 | 6837.8 |
| Tmax (hr) | 2 | 4 | 4 | 2 |
| AUC 0-last (hr*ng/ml) | 6745.4 | 39156.9 | 66323.6 | 112957.1 |
| AUC inf (hr*ng/ml) | 6812.1 | 39513.7 | 66751.7 | 114227.6 |
| HL (hr) | 7.48 | 7.32 | 6.49 | 7.16 |
Pharmacokinetic parameters analysis in mice after single oral treatment of 4 doses of Bio-nFeR: 10, 50, 100 and 200 mg/ /kg. Cmax: maximum plasma concentration achieved after drug administration; Tmax: time until Cmax is reached; AUC last: experimental area under the concentration-time curve from time 0 to the last experimental point measured (Clast); AUC inf: AUC calculated from 0 to Clast added of the extrapolated portion of the AUC calculated by: AUCz = Clast/ke; HL: plasma half-life of the terminal phase calculated by: HL = 0.693/ke.