Table 1. Characteristics of the Study Sample Based on Plasma Amylin Concentration.
| Characteristic | Mean (SD) | df | F Score | P Value | |||
|---|---|---|---|---|---|---|---|
| Total (N = 3061) | Low Plasma Amylin (n = 2752)a | High Plasma Amylin (n = 222)b | Extremely High Plasma Amylin (n = 87)c | ||||
| Age, y | 61.0 (9.5) | 61.1 (9.5) | 59.8 (9.0) | 61.8 (10.4) | 2 | 2.34 | .10 |
| Education, y | 14.1 (2.6) | 14.1 (2.6) | 14.4 (2.7) | 14.0 (2.6) | 2 | 1.58 | .21 |
| Women, No. (%) | 1653 (54.0) | 1494 (54.3) | 111 (50.0) | 48 (55.2) | 2 | 1.57 | .46 |
| BMI | 28.1 (5.3) | 28.2 (5.4) | 27.8 (5.1) | 27.0 (4.2) | 2 | 2.50 | .08 |
| Waist circumference, cm | 99.8 (14.0) | 99.8 (14.0) | 99.1 (14.0) | 97.0 (11.9) | 2 | 1.94 | .14 |
| Hip circumference, cm | 105.2 (10.4) | 105.2 (10.7) | 105.2 (9.7) | 102.9 (9.1) | 2 | 2.16 | .12 |
| SBP, mm Hg | 126.9 (18.7) | 127.0 (18.8) | 126.0 (18.8) | 127.2 (18.4) | 2 | 0.26 | .77 |
| DBP, mm Hg | 74.0 (9.7) | 74.0 (9.8) | 73.7 (9.6) | 74.2 (9.0) | 2 | 0.13 | .88 |
| Diabetes, No. (%) | 343 (11.2) | 312 (11.3) | 21 (9.5) | 10 (11.5) | 2 | 0.74 | .69 |
| CVD, No. (%) | 300 (11.3) | 273 (11.5) | 21 (10.7) | 6 (7.4) | 2 | 1.40 | .50 |
| Glucose, mg/dL | 104.2 (26.4) | 104.2 (26.3) | 103.1 (26.8) | 105.0 (30.1) | 2 | 0.22 | .80 |
| Total cholesterol, mg/dL | 200.5 (36.8) | 200.4 (36.7) | 202.0 (37.8) | 198.2 (36.2) | 2 | 0.36 | .70 |
| Triglycerides, mg/dL | 137.0 (88.7) | 136.8 (88.5) | 139.8 (99.3) | 134.7 (63.3) | 2 | 0.15 | .86 |
| LDL, mg/dL | 119.6 (32.7) | 119.6 (32.7) | 122.5 (33.8) | 120.7 (31.2) | 2 | 0.79 | .45 |
| HDL, mg/dL | 53.9 (17.0) | 54.1 (17.0) | 52.6 (17.4) | 50.4 (15.4) | 2 | 2.64 | .07 |
| Creatinine, mg/dL | 0.9 (0.3) | 0.9 (0.3) | 0.9 (0.2) | 0.8 (0.2) | 2 | 0.98 | .37 |
| CRP, mg/L | 4.3 (7.6) | 4.2 (6.2) | 5.3 (17.9) | 3.4 (4.3) | 2 | 2.66 | .07 |
| APOE4, No. (%) | 634 (20.7) | 570 (20.7) | 41 (18.5) | 23 (26.4) | 2 | 2.42 | .30 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CRP, C-reactive protein; CVD, cardiovascular disease; DBP, diastolic blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SBP, systolic blood pressure.
SI conversion factors: To convert glucose to millimoles per liter, multiply by 0.0555; total cholesterol, LDL, and HDL to millimoles per liter, multiply by 0.0259; triglycerides to millimoles per liter, multiply by 0.0113; creatinine to micromoles per liter, multiply by 88.4; and CRP to nanomoles per liter, multiply by 9.524.
Plasma amylin concentration, less than 75 pmol/L.
Plasma amylin concentration, 75 pmol/L to less than 2800 pmol/L.
Plasma amylin concentration, 2800 pmol/L or greater.