Table 2. Comparisons of AD Incidence Stratified by Plasma Amylin Concentration.
| Subgroup | No. (%) | df | Log-Rank Test | P Value | ||
|---|---|---|---|---|---|---|
| Low Plasma Amylin (n = 2752)a | High Plasma Amylin (n = 222)b | Extremely High Plasma Amylin (n = 87)c | ||||
| Dementia | 185 (6.7) | 10 (4.5) | 15 (17.2) | 2 | 15.4 | <.001 |
| AD incidence | 152 (5.5) | 5 (2.3) | 12 (13.8) | 2 | 15.7 | <.001 |
| Men | 1258 (45.7) | 111 (50.0) | 39 (44.8) | |||
| AD incidence | 59 (4.7) | 1 (0.9) | 2 (5.1) | 2 | 3.80 | .20 |
| Women | 1494 (54.3) | 111 (50.0) | 48 (55.2) | |||
| AD incidence | 93 (6.2) | 4 (3.6) | 10 (20.8) | 2 | 17.7 | <.001 |
| No diabetes | 2437 (88.7) | 201 (90.5) | 77 (88.5) | |||
| AD incidence | 117 (4.8) | 4 (2.0) | 9 (11.7) | 2 | 11.3 | .004 |
| Diabetes | 312 (11.3) | 21 (9.5) | 10 (11.5) | |||
| AD incidence | 35 (11.2)d | 1 (4.8) | 3 (30.0) | 2 | 4.1 | .10 |
| APOE2 | 380 (13.8) | 24 (10.8) | 9 (10.3) | |||
| AD incidence | 14 (3.7) | 1 (4.2) | 1 (11.1) | 2 | 1.10 | .60 |
| APOE3 | 1802 (65.5) | 157 (70.7) | 55 (63.2) | |||
| AD incidence | 83 (4.6) | 3 (1.9) | 6 (10.9) | 2 | 7.60 | .02 |
| APOE4 | 570 (20.7) | 41 (18.5) | 23 (26.4) | |||
| AD incidence | 55 (9.6)d | 1 (2.4) | 5 (21.7) | 2 | 6.20 | .05 |
Abbreviation: AD, Alzheimer disease.
a
Plasma amylin concentration, less than 75 pmol/L.
b
Plasma amylin concentration, 75 pmol/L to less than 2800 pmol/L.
c
Plasma amylin concentration, 2800 pmol/L or greater.
d
P < .001 for the column comparisons of AD incidence among plasma amylin concentration groups.