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. 2019 Aug 16;10:1960. doi: 10.3389/fimmu.2019.01960

Figure 5.

Figure 5

Effect of OxS on mRNA targets of co-ex and KO. (A) The expression of level of CCND1, CCND2, CCNE1, CDK7, IL-6, IL-10, TLR2, TLR3, STAT3, MYD88, IL-4, IL2RG, EGR2, PTEN, TNFSF12, MTDH, JUN, E2F3, BCL2, TNF, CDK2, MMP2, ARG1, AKT1, PPARA, and MYC, were significantly upregulated in co-ex males compared to females. The level of SMAD2 did not change between males and females. The expression levels were normalized to GAPDH and significant differences (P < 0.05) between sexes in co-ex are noted by an asterisk (*). (B) Similar analysis of the above genes was performed in KO males and females. Significant upregulation was observed for CCND1, CCND2, CCNE1, CDK7, IL-6, TLR2, TLR3, STAT3, MYD88, PTEN, TNFSF12, MTDH, JUN, E2F3, TNF, CDK2, SMAD2, and AKT1 in KO males, whereas the expression levels of IL-10, MMP2, ARG1, and PPARA were significantly upregulated in KO females. The expression levels were normalized to GAPDH and the significant differences (P < 0.05) between sexes in KO are noted by an asterisk (*).