Table 2.
Summary of Surgical Procedures, Anaplastic Thyroid Carcinoma Viability, Resected Tumor Histopathology, and Pretreatment Mutation Profile
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | |
|---|---|---|---|---|---|---|
| Procedures | TT, central ND, bilateral ND, limited resection of esophageal muscularis | TT, central ND, right ND, en bloc resection of right RLN | TT, central ND, left ND, en bloc resection of left RLN, shave resection of trachea | TT, central ND, revision right ND, left ND, resection of dermal metastasis | TT, central ND, left level IV ND, and resection of occipital scalp lesion | TT, central ND |
| Resection of ATC | Complete | Complete | Complete | Complete | Complete | Complete |
| Residual (R) tumor classification | R1 | R0 | R1 | R0 | R0 | R0 |
| Resected ATC viability, %a | 50 | 5 | <5 | 0 | 0 | 0 |
| Additional component in resected tumor | PTC | PTC | PTC | PDTC, PTC | PTC | PTC |
| Pretreatment tumor mutations | BRAFV600E, TP53R175H, EGFR G322S, BRAF amplificationb | BRAFV600E, TP53Q331 a | BRAFV600E, TP53D208V, CDKN2ApE88 a | BRAFV600E | BRAFV600E, ATMI1986V, MCL1 duplication | BRAFV600E |
Indicated viability of the ATC component of the postneoadjuvant treatment resected primary thyroid tumor.
Detected in cell-free DNA.
ATC, anaplastic thyroid carcinoma; ND, neck dissection; PDTC, poorly-differentiated thyroid carcinoma; PTC, papillary thyroid carcinoma; RLN, recurrent laryngeal nerve; TT, total thyroidectomy.