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. 2019 Aug 16;10:1957. doi: 10.3389/fimmu.2019.01957

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Copyright © 2019 McFarlane, Mokgethi, Kaye, Hurdayal, Brombacher, Alexander and Carter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of L. donovani infection on the antibody response of L. donovani infected CD4⁺ T cell specific IL-4Rα deficient (Lck^creIL-4Rα^−/lox), wild-type control (IL-4Rα^−/lox), and global IL-4Rα^−/− mice. Antigen-specific IgG1 (A), IgG2a (B), the ratio of antigen-specific IgG2a/IgG1 (C) and total IgE serum levels are shown (D). Specific antibody titers were determined using an antigen-specific ELISA and total IgE levels were also determined using a direct ELISA assay. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 compared to WT control (IL-4Rα^−/lox), #p < 0.01, ##p < 0.01, ###p < 0.001 Lck^creIL-4Rα^−/lox compared to IL-4Rα^−/−. Representative data from one of two experiments performed (n = 5/group).