Table 1.
Phenotypic description of the 457 families with at least one offspring affected with ASD in the SPARK pilot study
| All offspring with ASD | ||||||||
|---|---|---|---|---|---|---|---|---|
| Role | n = 465 | Average age (years) of ASD diagnosis | Average age (years) at enrollment (SD) | Range of age (years) at enrollment | Intellectual disability (%) | Nonverbal (%) | Epilepsy (%) | ADHD (%) |
| Affected male offspring | 376 | 4.8 | 12.9 (8.4) | 1.5–44.6 | 22% (78/356) | 13% (46/356) | 7% (25/356) | 30% (106/356) |
| Affected female offspring | 89 | 5.6 | 12.8 (7.3) | 1.9–29.8 | 33% (28/84) | 10% (8/84) | 13% (11/84) | 23% (19/84) |
1379 individuals in 39 multiplex and 418 simplex families were genomically characterized, including 472 individuals (465 offspring and 7 parents) affected with ASD. All phenotypic variables are not available for all participants