Fig. 4.

Characterization of DOX@E-PSiNPs. a Colocalization of DiO, DOX, and PSiNPs in DOX@E-PSiNPs exocytosed from Bel7402 cells by confocal microscopy. Scale bar: 1 µm. b Hydrodynamic diameter of E-PSiNPs and DOX@E-PSiNPs by DLS. c Hydrodynamic diameter of E-PSiNPs incubating in PBS with or without 10% FBS for different time intervals. d Degradation behavior of PSiNPs, E-PSiNPs and DOX@E-PSiNPs in PBS at 37 °C. e In vitro DOX release profiles of DOX@PSiNPs and DOX@E-PSiNPs in PBS at pH 7.4 by dialysis bag. Data were presented as mean ± SD (n = 3). ***P < 0.001 (one-way ANOVA with Bonferroni’s multiple comparisons test for d and unpaired two-tailed Student’s t test for e). Source data are provided as a Source Data file