Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 23;10:3814. doi: 10.1038/s41467-019-11772-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Structure of the deneddylated CSN–CRL2 complex. a The fitted density map of deneddylated CSN–CRL2 structure determined by combining cryo-EM and XL-MS. Alignment of the CSN C-terminal helical bundle from the neddylated and deneddylated holocomplexes reveals differences in b CSN2 and c CUL2. d CSN1-ELOB interface established from the rotation of CUL2 in c. e RBX1 is clamped between CSN2 and CSN4. f Conformational changes in CSN6 in the absence of NEDD8