Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 23;9:12301. doi: 10.1038/s41598-019-48846-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Silencing of MT2 influences chemotherapy tumour pulmonary metastatic dissemination. K7M2 cells modified with shControl or shMT2 were injected intramuscularly into the thighs of SCID mice and administered with chemotherapy as described in the Methods section. (A) H&E staining of lung tissue sections. The scale bars represent 2 mm, except in the upper-left insert: Scale bar = 50 µm. (B) Boxplot specifying the metastatic surface. Results are expressed as percent of whole pulmonary tissue. a indicates a statistically significant difference vs. saline (p < 0.05); b indicates a statistically significant difference vs. shControl group (p < 0.05). (C) Boxplot specifying the number of metastatic nodules per field. a indicates a statistically significant difference vs. saline (p < 0.05); b indicates a statistically significant difference vs. shControl group (p < 0.05). (D) Spearman correlations between the relative metastatic surface, as expressed as percent of whole pulmonary tissue, and tumour volume as expressed as mm³. The black line shows the regression line. The determination coefficient R² and the significance of the F test (P-value) are also given. (E) Spearman correlations between the number of metastatic nodules per field, and tumour volume.