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. 2019 Aug 23;9:12320. doi: 10.1038/s41598-019-48795-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Validation of PGC-1α overexpression in skeletal muscle. Graph (a) shows relative mRNA levels of Pgc1a, fibronectin type III domain-containing protein 5 (Fndc5), interleukin 15 (Il15), vascular endothelial growth factor B (Vegfb), metalloproteinase inhibitor 4 (Timp4), and cathepsin B (Ctsb), normalized to reference genes 18S and Gapdh (Pfaffl method, resampling test). Image (b) shows relative mRNA levels of Bdnf in hippocampus and PFC, normalized to reference genes 18S, Actb and Tbp (Pfaffl method, resampling test; n.s.). Data expressed as median, with interquartile range as box and minimum and maximum values as whiskers for WT and MCK-PGC-1α animals (n = 5–6; **p < 0.01). Hp, hippocampus. PFC, pre-frontal cortex.