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. 2019 Aug 23;9:12320. doi: 10.1038/s41598-019-48795-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overexpression of PGC-1α in skeletal muscle does not influence hippocampal volume or cytogenesis in middle-aged animals. Graphs showing volumes of DG subregions (a) GCL (two-way ANOVA; n = 8–10; n.s.), (b) ML (two-way ANOVA, n = 8–10; sex effect, *p < 0.05; genotype and interaction effect, n.s.), and (c) hilus (two-way ANOVA; n = 8–10; n.s.) in 11-month-old female WT and transgenic animals. Graphs showing corresponding number of BrdU⁺ cells in the (d) DG, (e) ML and (f) hilus (two-way ANOVA; n = 9–14; genotype effect, *p < 0.05) 4 weeks after the first BrdU-injection. Data expressed as mean ± standard error of the mean (SEM) for WT and MCK-PGC-1α animals.