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. 2019 Aug 23;9:12320. doi: 10.1038/s41598-019-48795-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overexpression of PGC-1α in skeletal muscle does not protect against reduction of hippocampal neurogenesis in aging. (a) Images showing BrdU immunostainings of DG for 3- and 11-month-old animals 4 weeks after first BrdU-injection, with corresponding graphs representing number of BrdU⁺-cells in the SGZ and GCL for (b) 3- (two-way ANOVA; n = 6–10; n.s.) and (c) 11-month-old animals (two-way ANOVA; n = 9–14; n.s.). (d) Images showing NeuN/BrdU immunostainings of DG for 3- and 11-month-old animals with confocal picture from quantification of NeuN⁺/BrdU⁺-cells with corresponding graphs representing number of NeuN⁺/BrdU⁺-cells for (e) 3- (two-way ANOVA; n = 6–10; n.s.) and (f) 11-month-old animals (two-way ANOVA; n = 9–14; n.s.). Images showing (g) DCX immunostainings of DG for 3- and 11-month-old animals with corresponding graphs showing number of DCX⁺ cells for (h) 3- (two-way ANOVA; n = 6–10; n.s.) and (i) 11-month-old animals (two-way ANOVA; n = 7–9; n.s.). Data expressed as mean ± SEM for female and male WT and MCK-PGC-1α animals. Scale bars = 20 µm.