Fig. 7.

Pkhd1l1^fl/fl, Atoh1-Cre⁺ mice show progressive hearing loss. a, b DPOAE thresholds a and ABR thresholds b of Pkhd1l1^fl/fl, Atoh1-Cre⁻ and Pkhd1l1^fl/fl, Atoh1-Cre⁺ mice at 3, 6, 12 weeks, and 6 months show progressive hearing loss. Up-arrows indicate that even at the highest SPL test level (80 dB SPL), at least one mouse in the group had no detectable thresholds at that frequency. c Mean amplitude (left) and latency (right) as a function of sound intensity of 11.2 kHz pure tone pips in 6-month-old control Pkhd1l1^fl/fl, Atoh1-Cre⁻ (n = 7) and mutant Pkhd1l1^fl/fl, Atoh1-Cre⁺ (n = 12) mice. d Mean ABR waveforms in response to 11.2 kHz tone pips at 80 dB SPL from mutant (n = 9) and control (n = 7) mice. Data shown as mean ± s.e.m. *p < 0.05, **p < 0.001, ***p < 0.0001; by two-tailed Student’s t test. Source data are provided as a Source Data file