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. 2019 Aug 23;9:12294. doi: 10.1038/s41598-019-48749-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of high-sugar diet on microbiota at the phyla and family levels. At the Phyla level, Verrucomicrobia was elevated in high sugar fed mice (p < 0.01, FDR < 0.01), while Firmicutes and Tenericutes were depleted (p = 0.02, FDR < 0.04) (A). At the family level, Lachnospiraceae, Prevotellaceae, and Anaeroplasmataceae were significantly decreased by a high-sugar diet (p < 0.01, FDR < 0.02) while Verrucomicrobiaceae and Porphyromonadaceae were significantly elevated (p < 0.01, FDR < 0.02) (B). Data is shown as mean ± SEM of relative abundance. Chow: n = 5; HS: n = 5.