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. 2019 Aug 23;9:12317. doi: 10.1038/s41598-019-48566-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell stiffness is influenced by ECM composition, measured with AFM. After filtering the values of native matrices Young’s modulus values from cell-occupied matrices, the median of Young’s modulus values of normal, scar and Dupuytren’s fibroblasts shows that the composition of the different decellularized matrices, e.g. Amnion, DED, Epiflex, MatriDerm or XenoDerm, determines the fibroblast mechanics. The respective medians of the Young’s moduli values were presented in Table 4. Statistical results are reported in Materials and Methods section.