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. 2019 Aug 23;9:12329. doi: 10.1038/s41598-019-48243-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of AK gene signatures in lung adenocarcinomas. (a) Identification of AK-signature in TCGA Lung adenocarcinoma (LUAD) dataset (n = 521). AK-associated genes were identified by correlating AK expression with the rest of the coding genes in the dataset and ranked according to Pearson correlation coefficient. AK gene signatures were defined by ±0.3 cutoff of Pearson correlation coefficient. Percentage of prognostic genes in each AK-signature queried by PRECOG (b) and/or TCGA (c) survival Z-score. Genes with survival Z-score more than 2 or less than -2 were defined as prognostic genes. Number in the bar chart indicates the numbers of gene as prognostic or non-prognostic genes in AK-signature. XY plot distribution of PRECOG Lung Ad prognostic genes (d) and TCGA LUAD prognostic genes (e) in AK1 gene signature. XY plot distribution of PRECOG Lung Ad prognostic genes (f) and TCGA LUAD prognostic genes (g) in AK4 gene signature.