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. 2019 Aug 23;10:3821. doi: 10.1038/s41467-019-11820-7

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — H3K4me3 dynamics across meiotic substages. a H3K4me3 dynamics at DSB hotspots across five meiotic substages. H3K4me3 signals at DSB hotspots are normalized by the spike-in H4K4me3 mononucleosomes. Quantified H3K4me3 signal is shown in violin plot (lower panel). b H3K4me3 dynamics at different genomic elements in five sorted subpopulations of meiotic nuclei. HS hotspots, TSS transcription start sites. c Stage-specific H3K4me3 at TSSs recapitulate meiotic gene expression patterns. Genes with only one isoform are selected for this analysis. H3K4me3 profiles at TSSs are grouped into five clusters (top), while the respective mRNA levels are shown in the bottom panel. LE Leptonema, ZY Zygonema, PA Early and Late Pachynema, DI Diplonema. The number of transcripts per cluster (N) and Spearman correlation coefficient (R) for all transcripts are shown. Source data are provided as a Source Data file