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. 2019 Aug 23;10:3807. doi: 10.1038/s41467-019-11791-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Pax7 and Tpit are required for opening cognate enhancer landscapes. a Read density heatmaps showing assay for transposase-accessible chromatin using sequencing (ATACseq) signals (reads per kilobase of transcript, per million mapped reads (RPKM)) across the different pituitary lineages in a 4 kb window centered at melanotrope-specific ATAC peaks (left panel). Right panel shows corresponding ATACseq heatmaps in the ILs of WT, Pax7^+/−;Tpit^+/− (labeled Pax7^+/−) and Pax7^−/−;Tpit^+/− (labeled Pax7^−/−) mice. b Read density heatmaps showing ATACseq signals (RPKM) across the different pituitary lineages in a 4 kb window centered at pro-opiomelanocortin (POMC)-specific ATAC peaks (left panel). Right panel shows corresponding ATACseq heatmaps in the intermediate lobe of WT, Pax7^+/−;Tpit^+/− (labeled Pax7^+/−) and Pax7^−/−;Tpit^+/− (labeled Pax7^−/−) mice. c Genome browser view (Integrative Genomics Viewer (IGV)) of ATACseq profiles at POMC-specific ATACseq peaks in the different pituitary lineages and in ILs of Pax7^+/−;Tpit^+/−, Pax7^−/−;Tpit^+/−, and Pax7^+/−;Tpit^−/− mice