Table 1.
Anthropometric, biochemical and hormonal characteristics of control subjects and patients with active Cushing’s syndrome and after successful treatment
| Control subjects n=22 |
Active Cushing’s syndrome n=24 |
Cushing’s syndrome after treatment n=9 |
|
|---|---|---|---|
| Sex (men/women) | 6/16 | 6/18 | 1/8 |
| Age (years) | 46.6±2.2 | 48.9±2.4 | 55.2±3.6 |
| Body mass index (kg/m2) | 23.5±0.5 | 34.5±2.1* | 31.9±2.1*● |
| Weight (kg) | 69.6±1.7 | 86.2±3.1* | 82.0±5.9● |
| Waist circumference (cm) | 81.7±2.0 | 109.2±2.7* | 114.3±4.4* |
| % of total body fat | 28.0±1.7 | 41.6±1.1* | 43.3±1.5* |
| Fasting insulin (mIU/L) | 7.1±0.6 | 35.0±4.2* | 17.3±3.1*● |
| Fasting glucose (mmol/L) | 4.82±0.10 | 6.65±0.65* | 4.92±0.36 |
| HOMA-IR | 1.5±0.2 | 11.5±2.1* | 4.0±1.0● |
| HbA1c (%) | 3.49±0.09 | 5.36±0.40* | 4.41±0.27* |
| Cholesterol total (mmol/L) | 4.80±0.19 | 5.78±0.25* | 4.75±0.34 |
| HDL cholesterol (mmol/L) | 1.58±0.09 | 1.23±0.06* | 1.25±0.15* |
| LDL cholesterol (mmol/L) | 2.72±0.16 | 3.72±0.23* | 2.78±0.31 |
| Triacylglycerides (mmol/L) | 1.10±0.10 | 2.37±0.25* | 2.00±0.32* |
| CRP (mg/L) | 0.17±0.06 | 0.55±0.17* | Not assessed |
| C-peptide (nmol/L) | 0.61±0.04 | 1.42±0.13* | 1.33±0.17* |
| Plasma cortisol at 08:00 hrs (nmol/L) | 527±51 | 822±80* | 286±71● |
| Urinary cortisol/24 hrs (nmol/L) | Not assessed | 1143±306 | 108±21● |
| Plasma cortisol after 1 mg dexamethasone (nmol/L) | Not assessed | 535±78 | 85±38● |
Notes: Values are means±SEM. Statistical significance is from one-way ANOVA or ANOVA on Ranks. *p<0.05 vs control subjects, ●p<0.05 vs active Cushing’s syndrome.
Abbreviations: HOMA-IR, homeostatic model assessment of insulin resistance; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HbA1c, Glycated hemoglobin A1c; CRP, C-reactive protein.