Table 2.

Relationships of mRNA expression of selected genes for mitochondrial proteins in subcutaneous adipose tissue with other anthropometric, hormonal and biochemical parameters calculated in a combined population of the group of patients with Cushing’s syndrome and the control group (n=46)

		MT-ND 5	NDUFA12	SDHA	CYC1	COX4I1	ATP50	DLAT	CS
BMI	R	−0.26	−0.47	−0.605	−0.66	−0.495	−0.331	−0.409	−0.744
p	0. 136	0.004	≤0.001	≤0.001	0.003	0.052	0.015	≤0.001
WC	R	−0.428	−0.43	−0.622	−0.66	−0.447	−0.407	−0.454	−0.761
p	0.012	0.009	≤0.001	≤0.001	0.008	0.016	0.006	≤0.001
Weight	R	−0.361	−0.279	−0.464	−0.612	−0.321	−0.429	−0.484	−0.658
p	0.036	0.098	0.005	≤0.001	0.064	0.01	0.003	≤0.001
TF	R	−0.169	−0.49	−0.533	−0.444	−0.458	−0.06	−0.164	−0.537
p	0.344	0.003	0.001	0.008	0.008	0.733	0.353	0.001
INS	R	−0.168	−0.438	−0.551	−0.511	−0.377	−0.209	−0.315	−0.691
p	0.388	0.016	0.002	0.004	0.048	0.265	0.095	≤0.001
Gluc	R	−0.023	−0.17	−0.169	−0.304	−0.257	−0.133	−0.237	−0.318
p	0.897	0.32	0.321	0.071	0.14	0.444	0.169	0.066
HOMA-IR	R	−0.122	−0.464	−0.519	−0.523	−0.396	−0.161	−0.313	−0.697
p	0.531	0.01	0.003	0.003	0.036	0.401	0.097	≤0.001

Note: Bold text indicates statistical significance, p<0.05.

Abbreviations: BMI, body mass index, WC, waist circumference (cm), TF, % of total body fat, INS, insulin, Gluc, glucose, HOMA-IR, homeostatic model assessment of insulin resistance; MT-ND5, mitochondrially encoded NADH dehydrogenase 5; NDUFA12, NADH:ubiquinone oxidoreductase, subunit A 12; SDHA, succinate dehydrogenase subunit A; CYC1, cytochrome c1; COX4I1, cytochrome c oxidase subunit IV isoform 1; ATP50, ATP synthase peripheral stalk subunit OSCP; DLAT, dihydrolipoate-S-acetyltransferase; CS, citrate synthase.