Table 3.

Relationships of mRNA expression of selected genes for mitochondrial proteins in peripheral monocytes with other anthropometric, hormonal, and biochemical parameters calculated in a combined population of the group of patients with Cushing’s syndrome and the control group (n=46)

		MT-ND 5	NDUFA12	SDHA	CYC1	COX4I1	ATP50	DLAT	CS
BMI	R	0.225	0.053	0.341	0.248	0.356	0.355	0.23	0.439
p	0.147	0.729	0.026	0.108	0.024	0.021	0.132	0.003
WC	R	0.067	−0.06	0.386	0.26	0.354	0.293	0.264	0.298
p	0.669	0.7	0.012	0.097	0.025	0.059	0.087	0.052
Weight	R	0.051	−0.085	0.296	0.229	0.223	0.212	0.19	0.228
p	0.749	0.586	0.057	0.144	0.166	0.177	0.222	0.141
TF	R	0.067	−0.06	0.386	0.26	0.354	0.293	0.264	0.298
p	0.669	0.7	0.012	0.097	0.025	0.059	0.087	0.052
INS	R	0.157	0.253	0.4	0.277	0.325	0.348	0.389	0.478
p	0.352	0.124	0.014	0.097	0.057	0.035	0.016	0.003
Gluc	R	−0.093	−0.287	0.258	0.256	0.32	0.164	0.24	−0.041
p	0.544	0.056	0.09	0.093	0.039	0.287	0.112	0.789
HOMA-IR	R	0.093	0.146	0.422	0.297	0.386	0.356	0.416	0.406
p	0.585	0.385	0.011	0.079	0.024	0.033	0.011	0.013

Notes: The bold text indicates statistical significance, p<0.05.

Abbreviations: BMI, body mass index; WC, waist circumference (cm), TF, % of total body fat; INS, insulin; Gluc, glucose; HOMA-IR, homeostatic model assessment of insulin resistance; MT-ND5, mitochondrially encoded NADH dehydrogenase 5; NDUFA12, NADH:ubiquinone oxidoreductase, subunit A 12; SDHA, succinate dehydrogenase subunit A; CYC1, cytochrome c1; COX4I1, cytochrome c oxidase subunit IV isoform 1; ATP50, ATP synthase peripheral stalk subunit OSCP; DLAT, dihydrolipoate-S-acetyltransferase; CS, citrate synthase.