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. Author manuscript; available in PMC: 2019 Aug 23.
Published in final edited form as: Exp Eye Res. 2018 Jul 25;176:219–226. doi: 10.1016/j.exer.2018.07.014

Figure 3. Kcnj13 cKO mice exhibit scotopic and photopic visual function defects.

Figure 3.

While wild-type mice had normal scotopic ERG responses, Kcnj13 mutant mice have significantly reduced A-wave (A) and B-wave (B) amplitudes at the strongest flash intensity tested (25 cd*s/m2) between P15 and 2 months of age. Kcnj13 mutant mice have significantly reduced photopic cone responses (at 790 cd*s/m2) between P21 and 2M (C). Comparison of B-wave and A-wave amplitudes in WT and Kcnj13 mutant mice (D). Horizontal error bar (A-wave SEM), vertical error bar (B-wave SEM). Wild-type is drawn in black and Kcnj13 mutant in red. Number of mice used: P15: WT=8, MUT=7; P21: WT=13, MUT=9; 1M: WT=6, MUT=7; 2M: WT=4, MUT=5. Statistical analysis was performed using 2-way ANOVA with multiple comparisons and Sidak’s correction. Error Bars (SEM). P>0.05 (ns = not significant); 0.05≥P>0.01 (*); 0.01≥P>0.001 (**); P<0.001 (***).