Table 3.
Overall incidence (per 1,000 person-years) and hazard ratio for hepatic failure, renal failure, and heart failure stratified by sex and age using a time-dependent regression model.
| Variables | Men | Women | ||
|---|---|---|---|---|
| Statin | Statin | |||
| No (N = 4,353) | Yes (N = 579) | No (N = 3,090) | Yes (N = 632) | |
| Age < 50 | Age ≧ 50 | |||
| Statin | Statin | |||
| No (N = 1,418) | Yes (N = 181) | No (N = 6,025) | Yes (N = 1,030) | |
| Hepatic failure | ||||
| No. of events | 415 | 42 | 279 | 40 |
| Incidence rate | 17.1 | 9.45 | 15.0 | 7.88 |
| cHR (95% CI) | 1 (Reference) | 0.59 (0.43, 0.81)** | 1 (Reference) | 0.57 (0.41, 0.80)** |
| aHR (95% CI) a | 1 (Reference) | 0.54 (0.38, 0.75)*** | 1 (Reference) | 0.47 (0.33, 0.67)*** |
| Renal failure | ||||
| No. of events | 334 | 43 | 176 | 31 |
| Incidence rate | 13.2 | 9.52 | 8.96 | 6.00 |
| cHR (95% CI) | 1 (reference) | 0.74 (0.54, 1.01) | 1 (reference) | 0.66 (0.45, 0.97)* |
| aHR (95% CI) a | 1 (reference) | 0.50 (0.36, 0.70)*** | 1 (reference) | 0.48 (0.33, 0.72)*** |
| Heart failure | ||||
| No. of events | 508 | 47 | 327 | 30 |
| Incidence rate | 20.8 | 10.5 | 17.5 | 5.81 |
| cHR (95% CI) | 1 (Reference) | 0.54 (0.40, 0.72)*** | 1 (reference) | 0.36 (0.25, 0.52)*** |
| aHR (95% CI) a | 1 (Reference) | 0.55 (0.40, 0.75)*** | 1 (reference) | 0.40 (0.27, 0.58)*** |
| Hepatic failure | ||||
| No. of events | 145 | 12 | 549 | 70 |
| Incidence rate | 15.2 | 7.76 | 16.5 | 8.78 |
| cHR (95% CI) | 1 (Reference) | 0.55 (0.30, 0.99)* | 1 (Reference) | 0.58 (0.45, 0.74)*** |
| aHR (95% CI) a | 1 (Reference) | 0.29 (0.15, 0.54)*** | 1 (Reference) | 0.53 (0.40, 0.68)*** |
| Renal failure | ||||
| No. of events | 33 | 5 | 477 | 69 |
| Incidence rate | 3.19 | 3.19 | 13.8 | 8.50 |
| cHR (95% CI) | 1 (Reference) | 1.02 (0.40, 2.62) | 1 (Reference) | 0.62 (0.48, 0.80)*** |
| aHR (95% CI) a | 1 (Reference) | 0.27 (0.10, 0.74)* | 1 (Reference) | 0.50 (0.38, 0.65)*** |
| Heart failure | ||||
| No. of events | 25 | 3 | 810 | 74 |
| Incidence rate | 2.41 | 1.90 | 24.7 | 9.18 |
| cHR (95% CI) | 1 (Reference) | 0.79 (0.24, 2.60) | 1 (Reference) | 0.40 (0.32, 0.51)*** |
| aHR (95% CI) a | 1 (Reference) | 0.35 (0.10, 1.26) | 1 (Reference) | 0.47 (0.37, 0.60)*** |
a
Adjusted for comorbidity of sleep disorder, diabetes, hypertension, hyperlipidemia, CAD, stroke, hepatitis B, and hepatitis C as well as ICS and OS use.
HD, cHR, crude hazard ratio; aHR, adjusted hazard ratio; ICS, inhaled corticosteroid; OS, oral steroid.
*P < 0.05, **P < 0.01, ***P < 0.001.