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. 2019 Aug 16;10:904. doi: 10.3389/fphar.2019.00904

Figure 6.

Figure 6

A hypothetical schematic diagram demonstration. (A) Anti-fibrotic; in the presence of AcSDKP, normal glucose, and lipid level, miR-29 and let-7 are found at normal expression level, whereas the expression level of miR-21 and miR-33 is down-regulated. (B) Profibrotic; in the absence of AcSDKP, the presence of hyperglycemia and hyperlipidemia suppresses the expression level of miR-29 and miR-let-7 but induces the expression level of profibrotic microRNA (miR-21 and miR-33) and influences mesenchymal activation in epithelial cells, endothelial cells, and M2 phenotype macrophages. Hyperglycemia is linked with up-regulation in the expression level of miR-21, whereas hyperlipidemia is found to be associated with miR-33. There would be a possibility that a kind of crosstalk mechanism exists among anti-fibrotic and pro-fibrotic microRNAs, which influences the EMT, EndMT, and MMT processes, and the endogenous peptide AcSDKP regulates such profibrotic mechanisms. Figures were created using the Servier Medical Art illustration resources.