PoMo state-space using . The four alleles represent the four nucleotide bases. Black and gray arrows indicate mutations, and genetic drift plus selection, respectively. Monomorphic or boundary states are represented in the tetrahedron’s vertices, while the polymorphic states are represented in its edges. Monomorphic states interact with polymorphic states via mutation, but a polymorphic state can reach a monomorphic state only via drift or selection. Between polymorphic states, only drift and selection events occur.