Table 2. Correlation of VMP1 mRNA with clinicopathological characteristics of breast tumors in cohort 1.
| Characteristic | n = 141 | VMP1 mRNA level median (25th, 75th) | p-value |
|---|---|---|---|
| Age | |||
| ≥ 50 | 85 | -0.23 (-0.59, 0.28) | 0.67 |
| < 50 | 56 | -0.28 (-0.78, 0.57) | |
| Estrogen receptor | |||
| positive | 90 | -0.20 (-0.59, 0.32) | 0.41 |
| negative | 47 | -0.39 (-1.03, 0.50) | |
| unknown | 4 | ||
| Progesterone receptor | |||
| positive | 70 | -0.19 (-0.57, 0.43) | 0.42 |
| negative | 64 | -0.31 (-0.97, 0.37) | |
| unknown | 7 | ||
| HER2 status | |||
| positive | 23 | 0.58 (0.02, 1.26) | 7x10-4* |
| negative | 117 | -0.36 (-0.75, 0.18) | |
| unknown | 1 | ||
| Receptors ER and HER2 | |||
| ER- and HER2- | 32 | -0.56 (-1.14, -0.10) | 6.4x10-6* |
| ER- and HER2+ | 14 | 0.51 (-0.13, 1.20) | |
| ER+ and HER2- | 82 | -0.24 (-0.59, 0.23) | |
| ER+ and HER2+ | 8 | 0.48 (0.29, 1.25) | |
| unknown | 5 | ||
| Tumor size (mm) | |||
| > 20 | 97 | -0.31 (-0.69, 0.40) | 0.90 |
| ≤ 20 | 44 | -0.14 (-0.62, 0.31) | |
| Histological type | |||
| IDCa | 121 | -0.14 (-0.65, -0.43) | 0.24 |
| ILCb | 12 | -0.35 (-0.56, -0.13) | |
| other | 8 | -0.37 (-0.74, -0.10) | |
| Nodal status | |||
| positive | 72 | -0.20 (-0.55, 0.57) | 0.16 |
| negative | 55 | -0.13 (-0.88, 0.38) | |
| unknown | 14 | ||
| Ki 67 | |||
| High | 41 | -0.46 (-0.85, 0.28) | 0.15 |
| Low | 97 | -0.17 (-0.53, 0.51) | |
| Unknown | 3 | ||
| Histological grade | |||
| 1 | 12 | -0.49 (-0.67, 0.26) | 0.08 |
| 2 | 80 | -0.15 (-0.52, 0.25) | |
| 3 | 48 | -0.25 (-0.80, 0.78) | |
| unknown | 1 | ||
| Metastasis | |||
| Positive | 59 | -0.14 (-0.52, 0.60) | 0.03* |
| Negative | 81 | -0.36 (-0.75, 0.25) | |
| unknown | 1 | ||
| Intrinsic subtype | |||
| Basal | 24 | -0.75 (-1.22, -0.14) | 5x10-6* |
| ERBB2 | 14 | 0.82 (0.37, 1.35) | |
| Luminal A | 43 | -0.24 (-0.51, 0.17) | |
| Luminal B | 30 | 0.03 (-0.56, 0.49) | |
| Normal-like | 12 | -0.47 (-0.87, -0.17) | |
| unknown | 18 | ||
| Familial status | |||
| BRCA2 | 27 | -0.43 (-0.89, 0.39) | 0.31 |
| Non-BRCA2 | 114 | -0.20 (-0.64, 0.38) |
The table shows the median and the 25th and 75th percentiles. One tumor was BRCA1 positive and it was not used in the familial status calculations. The p-value is calculated with log2 transformed data using a t-test or ANOVA.
*Significant difference p < 0.05.
aIDC: Invasive ductal tumors.
bILC: Invasive lobular tumors.