Table 2. Phenotypes of each mouse strain and heterozygous cross.
| Of Total | Of Total | Of Affected | Of Affected | ||||
|---|---|---|---|---|---|---|---|
| Genotype | Total n | Normal | Affected | Unilateral | Bilateral | Unilateral | Bilateral |
| C57BL/6J | 7 | 7 (100%) | - | - | - | - | - |
| Igf1(+/tg) | 7 | 7 (100%) | - | - | - | - | - |
| Igf1(tg/tg) | 5 | 5 (100%) | - | - | - | - | - |
| Gsk3β(+/-) | 13 | 11 (84.6%) | 2 (15.4%) | 1 (7.7%) | 1 (7.7%) | 1 (50%) | 1 (50%) |
| Twist1(+/-) | 17 | 11 (64.7%) | 6 (35.3%) | 5 (29.4%) | 1 (5.9%) | 5 (83.3%) | 1 (16.7%) |
| Gsk3β(+/-)/Igf1(+/tg) | 7 | 7 (100%) | - | - | - | - | - |
| Twist1(+/-)/Gsk3β(+/-) | 18 | 1 (5.6%) | 17 (94.4%) | 14 (77.8%) | 3 (16.7%) | 14 (82.4%) | 3 (17.6%) |
| Twist1(+/-) / Igf1(+/tg) | 17 | 9 (52.9%) | 8 (47.1%) | 3 (17.6%) | 5 (29.4%) | 3 (37.5%) | 5 (62.5%) |
Summary of craniosynostosis frequency and sub-phenotype (unilateral and bilateral) in mice with single and compound genotypes of interest