Table 4. Sex- and age- adjusted effects and corresponding 95% confidence intervals (95% CI) on body mass index (BMI) in linear regression models including main effects and interaction terms of a BMI-associated genetic risk score (GRSBMI), indicators of socioeconomic position (SEP; years of education and 1000€ income/month), SEP-related health behaviors (no physical activity [PA], current smoking [S], alcohol consumption [A; per 100g/week]) and a genetic risk score related to educational attainment (GRSEdu).
| Model 6—BMI ~ SEP + age + sex + GRSBMI + GRSBMI *SEP | Model 7—BMI ~ SEP + age + sex + GRSBMI + PA + GRSBMI *SEP + GRSBMI *PA + SEP*PA | Model 8—BMI ~ SEP + age + sex + GRSBMI + S + GRSBMI *SEP + GRSBMI *S + SEP*S | Model 9—BMI ~ SEP + age + sex + GRSBMI + A + GRSBMI *SEP + GRSBMI *A + SEP*A | Model 10—BMI~ GRSBMI + GRSEdu + GRSBMI*GRSEdu + sex+ age | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Education | β (95%-CI) | p | β (95%-CI) | p | β (95%-CI) | p | β (95%-CI) | p | β (95%-CI) | p |
| n | 4482 | 4482 | 4482 | 4376 | 4147 | |||||
| Intercept | -4.93 (-16.35; 6.49) | 0.4 | -0.22 (-12.19; 11.76) | 0.97 | -1.69 (-13.21; 9.84) | 0.77 | -3.09 (-14.70; 8.51) | 0.60 | 0.47 (-25.68; 26.63) | 0.97 |
| Age | 0.05 (0.04; 0.07) | 5.9*10−10 | 0.05 (0.03; 0.07) | 3.0*10−8 | 0.04 (0.02; 0.06) | 3.8*10−5 | 0.06 (0.04; 0.07) | 3.8*10−10 | 0.07 (0.05; 0.08) | 1.3*10−13 |
| Sex | -0.91 (-1.19; -0.63) | 1.8*10−10 | -0.81 (-1.09; -0.52) | 5.9*10−9 | -1.00 (-1.28; -0.71) | 6.5*10−12 | -0.96 (-1.26; -0.66) | 3.6*10−10 | -0.53 (-0.80; -0.25) | 1.9*10−4 |
| Education | 1.52 (0.73; 2.32) | <0.001 | 1.32 (0.51; 2.13) | 0.001 | 1.44 (0.64; 2.24) | 4.2*10−4 | 1.34 (0.52; 2.16) | 0.001 | - | - |
| GRSBMI | 0.37 (0.24; 0.49) | 7.9*10−9 | 0.31 (0.18; 0.44) | 2.7*10−6 | 0.36 (0.23; 0.48) | 2.5*10−8 | 0.35 (0.23, 0.48) | 4.5*10−8 | 0.26 (-0.03; 0.55) | 0.08 |
| GRSEdu | - | - | - | - | - | - | - | - | 0.20 (-0.16; 0.56) | 0.27 |
| PA | - | - | -4.16 (-8.46; 0.13) | 0.06 | - | - | - | - | - | - |
| S | - | - | - | - | -7.18 (-12.25; -2.12) | 0.01 | - | - | - | - |
| A | - | - | - | - | - | - | 0.14 (-1.77; 2.04) | 0.89 | - | - |
| GRSBMI x PA | - | - | 0.05 (0.002; 0.09) | 0.04 | - | - | - | - | - | - |
| GRSBMI x S | - | - | - | - | 0.03 (-0.02; 0.08) | 0.26 | - | - | - | - |
| GRSBMI x A | - | - | - | - | - | - | -0.01 (-0.03; 0.01) | 0.20 | - | - |
| Education x PA | - | - | 0.06 (-0.06; 0.17) | 0.32 | - | - | - | - | - | - |
| Education x S | - | - | - | - | 0.25 (0.11; 0.39) | 4.0*10−4 | - | - | - | - |
| Education x A | - | - | - | - | - | - | 0.06 (0.01; 0.12) | 0.02 | - | - |
| GRSBMI x Education | -0.02 (-0.03; -0.01) | 1.27*10−5 | -0.02 (-0.03; -0.01) | 1.5*10−4 | -0.02 (-0.03; -0.01) | 1.6*10−5 | -0.02 (-0.03; 0.01) | 8.9*10−5 | - | - |
| GRSBMI x GRSEdu | - | - | - | - | - | - | - | - | -0.002 (-0.006; 0.002) | 0.27 |
| Income | β (95%-CI) | p | β (95%-CI) | p | β (95%-CI) | p | β (95%-CI) | p | ||
| n | 4214 | 4218 | 4218 | 4128 | ||||||
| Intercept | 10.15 (5.17; 15.10) | 6.5*10−5 | 13.90 (8.30; 19.50) | 1.2*10−6 | 12.84 (7.67; 18.01) | 1.1*10−6 | 9.96 (4.92; 15.00) | 0.0001 | ||
| Age | 0.06 (0.04; 0.08) | 4.5*10−12 | 0.06 (0.04; 0.08) | 1.8*10−10 | 0.05 (0.03; 0.06) | 5.6*10−7 | 0.06 (0.05; 0.08) | 2.5*10−5 | ||
| Sex | -0.59 (-0.86; -0.31) | 3.0*10−5 | -0.50 (-0.78; -0.22) | 0.00042 | -0.62 (-0.90; -0.34) | 1.3*10−5 | -0.64 (-0.93; -0.34) | 2.3*10−12 | ||
| Income | 3.08 (-1.42; 7.58) | <0.01 | 2.84 (0.05; 5.63) | 0.05 | 3.22 (0.46; 5.99) | 0.02 | 3.08 (0.29; 5.87) | 0.03 | ||
| GRSBMI | 0.17 (0.11; 0.22) | 5.8*10−10 | 0.13 (0.07; 0.19) | 3.0*10−5 | 0.15 (0.10; 0.21) | 3.4*10−8 | 0.17 (0.12; 0.23) | 3.6*10−10 | ||
| GRSEdu | - | - | - | - | - | - | - | - | ||
| PA | - | - | -5.24 (-9.33; -1.15) | 0.01 | - | - | - | - | ||
| S | - | - | - | - | -5.37 (-10.20; -0.54) | 0.03 | - | - | ||
| A | - | - | - | - | - | - | 1.17 (-0.60; 2.93) | 0.20 | ||
| GRSBMI x PA | - | - | 0.06 (0.01; 0.10) | 0.01 | - | - | - | - | ||
| GRSBMI x S | - | - | - | - | 0.03 (-0.02; 0.09) | 0.19 | - | - | ||
| GRSBMI x A | - | - | - | - | - | - | -0.02 (-0.04; 0.002) | 0.07 | ||
| Income x PA | - | - | 0.59 (0.20; 0.98) | 0.003 | - | - | - | - | ||
| Income x S | - | - | - | - | 0.76 (0.32; 1.21) | 0.001 | - | - | ||
| Income x A | - | - | - | - | - | - | 0.23 (0.07; 0.40) | 0.01 | ||
| GRSBMI x Income | -0.05 (-0.08; -0.02) | 0.002 | -0.04 (-0.07; -0.01) | 0.01 | -0.04 (-0.07; -0.01) | 0.004 | -0.04 (-0.07; -0.01) | 0.01 | ||