Table 1. The basic parameters of photoresponses presented as ratios of post- and pretreated values, obtained in “outer segment out” configuration in Ringer’s solution and after 20 min incubation in drug-containing solution (mean ± SEM); * denotes p < 0.05 versus control, & denotes p < 0.05 versus 0.1% DMSO control.
| Light sensitivity | Aсtivation rate (A) | Turn-off time constant (τoff) | Dark current | Dominant recovery time constant (τD) | |
|---|---|---|---|---|---|
| Control |
0.99±0.04 |
0.75±0.06 |
1.01±0.05 |
1.06±0.04 |
1.01±0.05 |
| |
(n=10) |
(n=10) |
(n=10) |
(n=10) |
(n=10) |
| |
|
|
|
|
|
| Dopamine (0.1 µM) |
0.9±0.06 |
0.89±0.12 |
0.83±0.07 |
0.95±0.04 |
1.11±0.07 |
| |
(n=12) |
(n=12) |
(n=12) |
(n=12) |
(n=11) |
| |
|
|
|
|
|
| Dopamine |
0.74±0.07 |
0.72±0.07 |
0.97±0.14 |
1.02±0.07 |
1.04±0.04 |
| (2.5 µM) |
(n=10) * |
(n=10) |
(n=10) |
(n=10) |
(n=9) |
| |
|
|
|
|
|
| Dopamine (20 µM) |
0.66±0.06 |
0.57±0.10 |
0.8±0.11 |
0.99±0.04 |
0.92±0.08 |
| |
(n=9) * |
(n=9) |
(n=9) |
(n=9) |
(n=8) |
| Dopamine (50 µM) |
0.71±0.04 |
0.56±0.10 |
0.66±0.05 |
1.05±0.02 |
0.89±0.06 |
| |
(n=7) * |
(n=7) |
(n=7) |
(n=7) |
(n=7) |
| SKF-38,393 |
0.74±0.04 |
0.83±0.05 |
0.90±0.06 |
1.03±0.02 |
0.87±0.06 |
| (0.1 µM) |
(n=10) * |
(n=10) |
(n=10) |
(n=10) |
(n=10) |
| |
|
|
|
|
|
| SKF-38393 |
0.77±0.04 |
0.76±0.07 |
0.93±0.05 |
1.07±0.03 |
0.83±0.05 |
| (2.5 µM) |
(n=9) * |
(n=9) |
(n=9) |
(n=9) |
(n=9) |
| |
|
|
|
|
|
| SKF-38393 |
0.62±0.05 |
0.60±0.05 |
0.72±0.06 |
1.00±0.02 |
0.75±0.04 |
| (20 µM) |
(n=10) * |
(n=10) |
(n=10) * |
(n=10) |
(n=10) * |
| |
|
|
|
|
|
| SKF-38393 |
0.58±0.08 |
0.47±0.11 |
0.64±0.07 |
1.07±0.04 |
0.62±0.03 |
| (50 µM) |
(n=9) * |
(n=9) |
(n=9) * |
(n=9) |
(n=8) * |
| |
|
|
|
|
|
| Quinpirole (2.5 µM) |
0.86±0.09 |
0.85±0.07 |
1.05±0.11 |
1.05±0.03 |
0.98±0.08 |
| |
(n=9) |
(n=9) |
(n=9) |
(n=9) |
(n=8) |
| Quinpirole (20 µM) |
0.85±0.08 |
0.71±0.05 |
0.96±0.06 |
1.05±0.03 |
0.94±0.04 |
| |
(n=10) |
(n=10) |
(n=10) |
(n=10) |
(n=9) |
| Quinpirole (50 µM) |
0.74±0.02 |
0.68±0.05 |
0.82±0.05 |
1.11±0.06 |
0.95±0.03 |
| |
(n=11) * |
(n=11) |
(n=11) |
(n=11) |
(n=11) |
| Control |
1.00±0.03 |
1.11±0.08 |
1.08±0.10 |
1.03±0.02 |
1.11±0.04 |
| (0.1% DMSO) |
(n=5) |
(n=5) |
(n=5) |
(n=5) |
(n=5) |
| |
|
|
|
|
|
| SKF-83959 |
0.73±0.02 |
0.97±0.07 |
0.78±0.03 |
1.05±0.03 |
1.01±0.07 |
| (50 µM) | (n=10) & | (n=10) | (n=10) & | (n=10) | (n=5) |