Table 2. The magnitude of the “exchange current” and its decay time constant presented as ratio of post- and pretreated values, obtained in “outer segment out” configuration in Ringer’s solution and after 20 min incubation in drug-containing solution (mean ± SEM); & denotes p < 0.05 versus 0.1% DMSO control.
| “Exchange current” magnitude | “Exchange current” decay time constant | |
|---|---|---|
| Control |
1.05±0.05 |
0.99±0.07 |
| |
(n=8) |
(n=8) |
| |
|
|
| Dopamine |
1.15±0.08 |
1.28±0.17 |
| (50 µM) |
(n=6) |
(n=6) |
| |
|
|
| SKF-38393 |
1.09±0.14 |
1.09±0.27 |
| (50 µM) |
(n=7) |
(n=7) |
| |
|
|
| Quinpirole |
1.15±0.19 |
1.2±0.27 |
| (50 µM) |
(n=5) |
(n=5) |
| |
|
|
| Control |
1.00±0.08 |
1.09±0.21 |
| (0.1% DMSO) |
(n=6) |
(n=6) |
| |
|
|
| SKF-83959 |
1.27±0.05 |
1.24±0.06 |
| (50 µM) | (n=5) & | (n=5) |