Skip to main content
. 2019 Aug 23;14(8):e0221163. doi: 10.1371/journal.pone.0221163

Fig 3. Ingenuity pathway analysis (IPA) of JM6 effects on Huntington’s disease (HD) pathway.

Fig 3

(A) JM6 treatment downregulates the expression of HD genes associated with cell death, calpain and caspase (green) and upregulates a gene associated with cell survival, Akt (red). (B) In silico analysis of drug-affected miRNAs after JM6 treatment, miRNAs affected by TBI and returned to sham patterns by JM6 treatment (shown enlarged) are associated with depression-linked genes. (C) List of genes associated with depression are regulated by broadly conserved miRNAs affected by TBI and/or TBI+ JM6.