Table 1.
Incidence of PKU in China by province and severity, 2013–2017
| Province or municipality | Cases | Incidence (95% CI) per 100 000 neonates screened | PKU severity, n (% of all PKU cases) | |
| Mild | Classical | |||
| Gansu | 428 | 28.63 (25.98 to 31.48) | 168 (39.25) | 260 (60.75) |
| Ningxia | 93 | 19.00 (15.34 to 23.28) | 42 (45.16) | 51 (54.84) |
| Qinghai | 48 | 17.37 (12.81 to 23.03) | 17 (35.42) | 31 (64.58) |
| Shanxi | 243 | 15.17 (13.32 to 17.20) | 92 (37.86) | 151 (62.14) |
| Xinjiang | 184 | 13.22 (11.38 to 15.27) | 113 (61.41) | 71 (38.59) |
| Liaoning | 197 | 12.23 (10.58 to 14.06) | 81 (41.12) | 116 (58.88) |
| Inner Mongolia | 58 | 10.87 (8.25 to 14.05) | 25 (43.10) | 33 (56.90) |
| Hebei | 520 | 10.78 (9.88 to 11.75) | 231 (44.42) | 289 (55.58) |
| Beijing | 124 | 10.58 (8.80 to 12.62) | 40 (32.26) | 84 (67.74) |
| Jilin | 94 | 10.58 (8.55 to 12.95) | 47 (50.00) | 47 (50.00) |
| Shaanxi | 232 | 10.46 (9.16 to 11.90) | 107 (46.12) | 125 (53.88) |
| Heilongjiang | 98 | 9.89 (8.03 to 12.05) | 44 (44.90) | 54 (55.10) |
| Tianjin | 57 | 9.79 (7.42 to 12.69) | 20 (35.09) | 37 (64.91) |
| Shandong | 629 | 9.31 (8.59 to 10.06) | 269 (42.77) | 360 (57.23) |
| Jiangsu | 365 | 8.28 (7.45 to 9.17) | 215 (58.90) | 150 (41.10) |
| Anhui | 292 | 7.94 (7.05 to 8.90) | 139 (47.60) | 153 (52.40) |
| Henan | 475 | 7.80 (7.12 to 8.54) | 224 (47.16) | 251 (52.84) |
| Shanghai | 56 | 5.25 (3.97 to 6.82) | 36 (64.29) | 20 (35.71) |
| Yunnan | 133 | 5.04 (4.22 to 5.97) | 67 (50.38) | 66 (49.62) |
| Zhejiang | 135 | 4.01 (3.37 to 4.75) | 92 (68.15) | 43 (31.85) |
| Hubei | 118 | 3.96 (3.28 to 4.74) | 75 (63.56) | 43 (36.44) |
| Hunan | 78 | 2.01 (1.59 to 2.51) | 34 (43.59) | 44 (56.41) |
| Sichuan | 75 | 1.98 (1.55 to 2.48) | 50 (66.67) | 25 (33.33) |
| Chongqing | 24 | 1.77 (1.13 to 2.63) | 11 (45.83) | 13 (54.17) |
| Guizhou | 37 | 1.74 (1.23 to 2.41) | 22 (59.46) | 15 (40.54) |
| Fujian | 44 | 1.47 (1.07 to 1.97) | 37 (84.09) | 7 (15.91) |
| Jiangxi | 32 | 1.29 (0.88 to 1.82) | 16 (50.00) | 16 (50.00) |
| Hainan | 7 | 1.11 (0.45 to 2.29) | 0 (0.00) | 7 (100.00) |
| Guangdong | 43 | 0.53 (0.39 to 0.72) | 24 (55.81) | 19 (44.19) |
| Guangxi | 6 | 0.15 (0.05 to 0.32) | 6 (100.00) | 0 (0.00) |
| Total | 4925 | 6.28 (6.11 to 6.46) | 2344 (47.59) | 2581 (52.41) |
CI, Confidence Interval; PKU, phenylketonuria.