Table 1.
Inclusion and exclusion criteria
| Inclusion criteria | |
| Antenatal maternal | |
| 1 | History of doctor-diagnosed atopy (atopic eczema, asthma or hay fever) in the woman, her partner or other child the couple have parented. |
| 2 | Woman aged 18 years or older. |
| 3 | Woman able to understand English. |
| 4 | Lives in a hard water area (>250 mg/L calcium carbonate). |
| 5 | Lives in a property suitable to have a water softener fitted. |
| 6 | If in a rented property—agrees to seek consent of landlord for fitting of water softener device. |
| 7 | Agrees to have water softener±additional tap for drinking water fitted at home. |
| 8 | Agrees to researchers accessing pregnancy and pregnancy outcome data for the mother and child. |
| 9 | Able and willing to give informed consent. |
| Postnatal maternal | |
| 10 | Maternal consent for her neonate to participate in the study. |
| Exclusion criteria | |
| 11 | Preterm birth (defined as birth prior to 37 weeks’ gestation). |
| 12 | Significant inflammatory skin disease at birth not including seborrheic dermatitis (‘cradle cap’). |
| 13 | Sibling (including twin) previously randomised to this trial. If multiple birth, the first child will be randomised into the trial. |
| 14 | Any immunodeficiency disorder or severe genetic skin disorder. |
| 15 | Child has any other serious health issue which, at parent or investigator discretion, would make it difficult for the family to take part in the trial. |
| 16 | Planned stays away from home for a continuous period of more than 2 weeks or a total of 1 month out of the 6-month follow-up period. |
| 17 | Water softening or filtration device already installed. |
| 18 | Concurrent enrolment in any other skin-related intervention study. |
| 19 | Other medical condition that in the opinion of the chief investigator could interfere with the conduct of the trial. |