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. 2019 Aug 22;25:446–461.

Figure 4.

Figure 4

DMF treatment preserves RGCs. Representative photomicrographs and accompanying graphs showing average total regional retinal ganglion cells (RGCs) in mice treated with either dimethyl fumarate (DMF; blue squares) or vehicle (red triangles). Data from the preventive regimen for the more affected eye (MA; A) and the less affected eye (LA; B). Data for the interventional regimen, the MA eye (C) and the LA eye (D). All photomicrographs were captured with a 20X inverted objective. Error bars represent the standard error of the mean (SEM). All statistical analysis performed with the linear mixed-effects model. **** p<0.0001; *** p<0.001; ** p<0.01; * p<0.05; ns p>0.05 by differential effect. n=9 mice per group for the preventive group and n=8 mice per group for the interventional group.