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View full-text article in PMC

. 2019 Aug 22;25:446–461.

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Copyright © 2019 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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DMF does not induce the Nrf2 target genes HO-1 and NQO1 in the optic nerves or spinal cords of mice experiencing acute EAE. Quantitative real-time PCR (qPCR) data measuring the mRNA expression of the Nrf2 target genes HO-1 and NQO1 from either the optic nerves of the more affected (MA) eyes (A and B) or the spinal cords (C and D) of mice subjected to the indicated treatment regimens. Data graphed as the fold change in the expression of the dimethyl fumarate (DMF)-derived samples compared to that of the vehicle-derived samples. Each qPCR reaction was performed in triplicate (three technical replicates) on the indicated number of mice. Error bars represent ± standard deviation (SD). Data were analyzed with the Student t test, with p<0.05 indicating statistical significance; no values reached statistical significance. ON = optic nerve; SC = spinal cord.