Figure 5.

Exercise prevents increases in TUNEL-positive cells following induction of I307N Rho retinal degeneration. The active and inactive I307N Rho mice received toxic light exposure and were euthanized 1 week after exposure. Retinas were collected, sectioned, and sections were assayed for terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL). A: Representative morphological images of each group are from the region of 250–750 μm from the optic nerve. Complete sections are shown in Appendix 6. B: TUNEL-positive cells were counted across complete retina sections. The uninduced mice had few TUNEL-positive cells (black bar). Induction statistically significantly increased the number of TUNEL-positive cells per section (red bar). This increase did not occur in the active mice (green bar). *p<0.05 versus other groups with one-way ANOVA with the Newman-Keuls multiple comparisons test. n=3 sections/group. Error bars represent standard error of the mean (SEM). Size marker represents 50 µm.