Table 2.
Performance measures among current available asthma predictive models.
| Asthma predictive model | Sensitivity | Specificity | Positive | Negative | Positive | Negative |
|---|---|---|---|---|---|---|
| PV | PV | LR | LR | |||
| (13) Original API (stringent index) | ||||||
| At 6 years | 28 | 96 | 48 | 92 | 7.43 | 0.75 |
| At 8 years | 16 | 97 | 44 | 88 | 4.9 | 0.86 |
| At 11 years | 15 | 96 | 42 | 86 | 3.9 | 0.88 |
| At 13 years | 16 | 97 | 52 | 84 | 4.9 | 0.9 |
| (14) Isle of Wight (score strata ≥3) | ||||||
| At 10 years | 53 | 85 | 68 | 74 | 3.41 | 0.56 |
| (15) PIAMA (cutoff ≥ 20) | ||||||
| At 7–8 years | 60 | 76 | 23 | 94 | 2.5 | 0.53 |
| (16) mAPI (from year 3) | ||||||
| At 6 years | 17 | 99 | 72 | 9 | 21 | 0.84 |
| At 8 years | 19 | 100 | 87 | 9 | 55 | 0.83 |
| At 11 years | 19 | 99 | 70 | 9 | 19 | 0.82 |
| (17) ucAPI At 7 years | 44 | 94 | 60 | 89 | 7.5 | 0.6 |
| (18) APT At 6–8 years | 72 | 71 | 49 | 86 | 2.5 | 0.4 |
| (19) ademAPI* At 6 years | 88 | 90 | 90 | 89 | 8.8 | 0.13 |
*
Final model: API plus 9/17 volatile organic components and 3/31 gene expression markers. API, asthma predictive index; APT, asthma predictive tool; PV, predictive value; LR, likehood ratio; Positive LR, sensitivity/1-specificity; Negative LR, 1-sensitivity/specificity.